I don't have any real data on the 21 psi pulley. However in theory there is a point of dimishing returns where the added boost increases both charge temperatures and pressures, thus requiring the spark retardation to prevent detonation. At some point this loss of power from spark retarded is greater than the power gain from more boost. Also the intercooler setup will be working harder making heat soak at bigger problem. It really depends on how you are going to drive it and under what conditions. If you only do 10 seconds pulls with rest periods in between in cool weather, it probably will work fine with the right tune. If you plan to do an open track on a road course during the summer time in TX is wouldn't be wise.
e.g. I am using the 19 psi pulley and at Thunderhill and driving like granny, on a cool ~70F outside temperatures, my air intake temps were 84F pre-blower and 138F post blower. This was data from a 7 second pull from 2400 to 5900 rpm. ACT2 started at 128F and rose to 138F during that time. I was running 91 octane. I think even on this cool day the 21 pulley would have been too much since ACT2 would surely be much greater than 138F. Just think what the temp would be an a hot 105F day in AZ!